Oxymetholone (also known as anapolon or anadrol) is a very drastic synthetic steroid, 17-alpha-alkylated modification of dihydrotestosterone. It was developed for the treatment of osteoporosis and anaemia, as well as to stimulate muscle gain in malnourished and debilitated patients. Oxymetholone has been approved by the American Food and Drug Administration (FDA) for use in humans. Later there where created non-steroidal drugs that effectively could treat anaemia and osteoporosis; because of this anapolon lost his popularity and by 1993 Syntex decided to cease the production of the drug, as well as other manufacturers did.
By its performance parameters oxymetholone is most similar to methandienone. As with methandienone, it provokes not only active muscle bulking, but also a significant increase in power performance. However, a large part of the gained weight is because of water retention in the body, which can lead to high blood pressure on cycle.
Thanks to its ability to influence the level of hemoglobin and to increase the blood volume in the body, oxymetholone may cause an extremely strong pumping effect by athletes, which consequently complicates the training process, because muscles get sore almost immediately after the first heavy set.
Oxymetholone is a derivative of dihydrotestosterone, which gives it a chemical structure that does not aromatize. Despite the fact that oxymetholone does not directly convert to estradiol, it itself has pronounced estrogenic properties. It should be remembered that because of this peculiarity only antiestrogens would be able to combat with estrogenic side effects, but not aromatase inhibitors, because aromatase is not involved into the process.
Some suggest that oxymetholone`s estrogenic activity relates to the progestogenic one, like with nandrolones. Side effects may be similar. However, medical studies have shown that oxymetholone does not possess any progestogenic activity.
Athletes who are more advanced or weigh more than 220 pounds can increase the dosage to 150 mg/day in the third week. This dosage, however, should not be taken for periods longer than two to three weeks. Following, the dose should be reduced by one tablet every week. Since Anadrol 50 quickly saturates the receptors, its intake should not exceed six weeks. The dramatic mass build up which often occurs shortly after administration rapidly decreases, so that either the dosage must be increased (which the athlete should avoid due to the considerable side effects) or, even better, another product should be used. Those who take Anadrol 50 for more than 5-6 weeks should be able to gain 20 – 25 pounds. These should be satisfying results and thus encourage the athlete to discontinue using the compound.