The elimination of Warfarin is almost entirely by metabolism. Warfarin is stereoselectively metabolized by hepatic cytochrome P-450 (CYP450) microsomal enzymes to inactive hydroxylated metabolites (predominant route) and by reductases to reduced metabolites (Warfarin alcohols) with minimal anticoagulant activity. Identified metabolites of Warfarin include dehydroWarfarin, two diastereoisomer alcohols, and 4′-, 6-, 7-, 8-, and 10- hydroxyWarfarin. The CYP450 isozymes involved in the metabolism of Warfarin include CYP2C9, 2C19, 2C8, 2C18, 1A2, and 3A4. CYP2C9, a polymorphic enzyme, is likely to be the principal form of human liver CYP450 that modulates the in vivo anticoagulant activity of Warfarin. Patients with one or more variant CYP2C9 alleles have decreased S-Warfarin clearance [see Clinical Pharmacology ( )] .
Oxandrolone (Anavar), is especially well suited with cutting cycle and many people is using for this purpose. By using Anavar you will not notice a big difference in gain of mass, but any mass that you gain it will be lean tissue. It is knowns as well as “Girl Steroid”. Female users are more likely to see gains in tissue. Using this steroid, it means that does not aromatize to estrogen, water retention is reported as quite law and gyno is not shown at all. After 5 days of administration of Anavar, there are noticeable results as 44% increase in muscle cell protein synthesis. Benefits of Anavar BD Max:· Doesn’t aromatize· Water retention is law· Liver toxic less than other drugs· Fat burningSpecification:· Active Life - 8-12 hours· Average Dose - 15-60 mg/daily· Aromatization - No..