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Access to medication can be poor even where health care is provided free. In a patient survey conducted by the United Kingdom 's National Health Service in 2008, 5% of respondents acknowledged resorting to self-medication, and 46% were dissatisfied with the amount of time it took to receive hormone therapy. The report concluded in part: "The NHS must provide a service that is easy to access so that vulnerable patients do not feel forced to turn to DIY remedies such as buying drugs online with all the risks that entails. Patients must be able to access professional help and advice so that they can make informed decisions about their care, whether they wish to take the NHS or private route without putting their health and indeed their lives in danger." [9] Self-administration of hormone replacement medications may have untoward health effects and risks. [10]

In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed. [16] In patients with dysthymia , unipolar , and bipolar depression significant improvement was observed. [16] In this series of studies, mesterolone lead to a significant decrease in luteinizing hormone and testosterone levels. [16] In another study, 100 mg mesterolone cipionate was administered twice monthly. [17] With regards to plasma testosterone levels, there was no difference between the treated versus untreated group, and baseline luteinizing hormone levels were minimally affected. [17]

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