Clomid is similar to estrogen in its make-up. The receptor cells in your brain think that Clomid is estrogen which allows the Clomid to attach to the receptor cells. When Clomid attaches to the receptor cells, it keeps your own estrogen from attaching to the cells. This causes your body to think that you are not making enough estrogen. When estrogen levels are low, your body responds by making other hormones that help nurture and mature the follicles that are growing in your ovaries. Why? Because the follicles are what produce estrogen and your body wants your estrogen levels to increase. Your body thinks your follicles are not producing enough estrogen so it starts producing more of the hormones that help the follicles mature so that they will start producing more estrogen.